• JSH-23 and the Next Evolution in NF-κB Inhibition: Mechan...

  2025-10-22

  This thought-leadership article explores the mechanistic underpinnings and translational potential of JSH-23—a small-molecule inhibitor targeting NF-κB p65 nuclear translocation. By integrating recent experimental findings, competitive analysis, and strategic recommendations, we provide a roadmap for leveraging JSH-23 in inflammation research and advanced disease modeling. We contextualize JSH-23’s unique profile against standard NF-κB inhibitors, highlight its selective inhibition of transcriptional activity, and discuss its relevance to emerging in vivo applications, including kidney injury models and cytokine regulation. The article also critically examines the nuances of NF-κB pathway modulation in light of recent airway epithelium studies, offering new vistas for translational investigators.

• Redefining Cancer Metabolism: How 7ACC2 Unlocks New Front...

  2025-10-21

  This thought-leadership article examines how the carboxycoumarin MCT1 inhibitor 7ACC2 is reshaping cancer metabolism research. It explores mechanistic insights into lactate transport inhibition, mitochondrial pyruvate blockade, and the immunometabolic reprogramming of the tumor microenvironment. Drawing on recent breakthroughs in TAM metabolic regulation, the article provides strategic guidance for translational researchers seeking to leverage 7ACC2 for next-generation cancer therapy discovery.

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